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Topical monomethylsilanetriol can deliver silicon to the viable skin

Summary

This blog article discusses the findings of a study that aimed to determine whether monomethylsilanetriol (MMST) can deliver organic silicon to the skin's epidermis and dermis when applied topically in a cream.

Objective

Silica has been linked to positive effects on skin rejuvenation, mainly by the oral route. Thus, the main objective of the present study was to assess whether monomethylsilanetriol (MMST, a source of organic silicon) can deliver silicon to the epidermis and dermis when applied topically in a cream. Once the hypothesis was confirmed, the present study also evaluated whether the product was toxic to keratinocytes; additionally, its possible antioxidant activity was assessed.

Methods

The ex vivo skin permeation profile was determined using human skin in Franz‐cells equipment; cytotoxicity was assessed using HaCaT keratinocytes. Antioxidant capacity was determined as scavenging activity, measured according to the 1,1‐diphenyl‐2‐picrylhydrazil free radical method.

Results

The permeation percentage was almost 60% of the applied MMST, with a large quantity of the drug found in the viable epidermis and dermis. The cell viability assay showed no significant difference in the percentage of viable keratinocytes among the treated groups at the doses used. In terms of antioxidant activity, the IC50 value obtained was 2400 μg mL−1. Low antioxidant activity, negligible toxicity for keratinocytes, and a significant percentage of permeation were observed.

Conclusion

We provide evidence that MMST applied topically can deliver silicon to the skin in biorelevant levels for cosmetic purposes.

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